Cell Signaling Technology

Research Associate I - Immunohistochemistry

Job ID
Job Locations
Posted Date
3 months ago(4/19/2022 1:48 PM)
Product Development

Company Overview

About CST

Cell Signaling Technology (CST) is a private, family owned, global leader in the development and commercialization of antibodies, assays, and research tools. As a company of scientists for scientists, we have developed XMT® technology, a proprietary method to develop exceptional monoclonal antibodies, PTMScan®, a technology to discover protein post-translational modifications, and PhosphoSitePlus®, an online resource for investigation of post-translational modifications. We are passionate about our role in contributing to the life science industry’s advancing of the human condition through accelerating the discovery and development of innovative therapies for human disease.  We are fully committed to developing new research tools to help define the mechanisms underlying cell function and disease, thereby broadly accelerating progress in biomedical research and medicine.


The role

Our team is growing, and we are seeking a highly self-motivated Research Associate to be part of our Immunohistochemistry Group. The mission of the Immunohistochemistry Group is to serve as a core provider of immunohistochemical analysis of cells and tissues in support of the Product Development and Production pipelines. This role will be responsible for delivery of high-quality paraffin-embedded cell pellets and tissues and continued monitoring of processes in order to reduce testing times. You will also be responsible for confirming the efficacy of treatments via western blot. You will have the opportunity to expand your skillset by learning the IHC assay and supporting testing needs as opportunities arise. While the primary responsibility of this role is developing model systems for IHC testing, you will have the chance to learn a number of new skills and work cross functionally with other groups throughout the company.


You'll have the opportunity to....

  • Perform sterile technique in Tissue Culture, including culturing and passaging cell lines.
  • Prepare high quality paraffin-embedded cell pellets to facilitate IHC testing.
  • Conduct scientific experiments including western blots to verify treatment efficacy.
  • Prepare paraffin-embedded animal tissues, syngeneic tumors, and xenografts in conjunction with the Animal Facility staff.
  • Maintain the inventory of paraffin-embedded human tissues, including sample logging and management of associated clinical data, when applicable. 
  • Maintain tissue processing and embedding equipment per established policies.
  • Support the execution of IHC testing as appropriate opportunities arise.
  • Assist the Western Blot Core by performing western blots in support of the development pipeline as needed. 
  • Maintain accurate and complete laboratory documentation in appropriate systems and testing databases in accordance with CST quality systems requirements.
  • Develop an understanding of the antibody development process and maintain an awareness of such as changes are implemented.
  • Understand and follow established protocols for all group processes and procedures as detailed in SOPs and training documents.
  • Seek opportunities that will improve quality, efficiency, or scalability of cell culture and other team processes.
  • Adhere to safety procedures in and around the laboratory. 


Who you are and what you bring to the team....

  • You should have a commitment to integrity, quality, collaboration, and innovation.
  • You have strong organizational skills and exceptional attention to detail.
  • You have experience multi-tasking with effective management of multiple, changing priorities.
  • You possess Bachelor’s degree in a biological science.
  • You have previous experience with tissue culture and/or sterile technique.
  • You pride yourself on being a strong communicator with excellent verbal, written, and presentation skills.
  • You are highly dependable and team focused.


What we offer....

At Cell Signaling Technology (CST) we recognize that people will always be our most important asset. Providing a safe, inclusive, and stimulating working environment that understands the importance of diversity, human dignity and meaningful work is as important as establishing company policies that incorporate excellent health insurance and pay benefits. We recognize that development of people is the key to their happiness and thus ensure every employee has impactful discussions with their manager and develops actionable performance and professional development plans. Lastly, we are committed to engaging and supporting our employees in committees and philanthropy that benefit their local communities and environment through community investment programs.



  • Medical (BCBS) and Dental (Delta Dental) plans paid at 90%
  • Vision Insurance
  • Life Insurance, Short and Long Term Disability
  • Flexible Spending accounts
  • 401(k) Plan with 6% match
  • Tuition Reimbursement
  • Generous PTO package
  • Pet Insurance
  • Employee Assistance Program
  • Onsite Subsidized Cafeteria
  • Free Parking


Our number one priority is the health and safety of our employees, their families, our communities, partners and customers. In order to promote that safety and well-being, we require that all US-based employees be fully vaccinated against COVID-19 by their start date. Applicants who receive an offer of employment who can provide documentation that the vaccine is medically contraindicated, or who object to vaccination due to a sincerely held religious belief, may make a request for exemption. We will consider requests for reasonable accommodations consistent with our policy, and where we are able to provide such accommodations without undue hardship to the company.


Cell Signaling Technology (CST) is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, status as a veteran or as a member of the military or status in any group protected by applicable federal or state laws.



All resumes submitted by search firms/employment agencies to any employee at Cell Signaling Technology (CST) via email, the internet or in any form and/or method will be deemed the sole property of CST, unless such search firms/employment agencies were engaged by CST for this position and a valid agreement with CST is in place. In the event a candidate who was submitted outside of the CST agency engagement process is hired, no fee or payment of any kind will be paid.



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