Cell Signaling Technology

Scientist, Oligonucleotide Chemistry

Job ID
Job Locations
Posted Date
3 months ago(4/2/2022 10:02 AM)

Company Overview

About CST

Cell Signaling Technology (CST) is a private, family owned, global leader in the development and commercialization of antibodies, assays, and research tools. As a company of scientists for scientists, we have developed XMT® technology, a proprietary method to develop exceptional monoclonal antibodies, PTMScan®, a technology to discover protein post-translational modifications, and PhosphoSitePlus®, an online resource for investigation of post-translational modifications. We are passionate about our role in contributing to the life science industry’s advancing of the human condition through accelerating the discovery and development of innovative therapies for human disease.  We are fully committed to developing new research tools to help define the mechanisms underlying cell function and disease, thereby broadly accelerating progress in biomedical research and medicine.


The role

The Multiplex Assays Development team is growing, and we are looking for a highly motivated and innovative Oligonucleotide Chemist who is passionate about collaborating with a team of scientists to develop and commercialize complex novel technologies for visualizing biology. A successful candidate will have the opportunity to independently design and execute on strategies to optimize oligonucleotide structures for use in multiplex biomolecule detection assays, including but not limited to multiplex immunohistochemistry, immunofluorescence, and in situ hybridization.  This cross-functional, team-oriented position requires strong communication skills and the ability to interface with scientist and other stakeholders. 


Our work is a wonderful blend of exciting science and beautiful art, and we love that! The ideal candidate should pride themselves on precise technical execution, find joy in discovery, thrive on a fun and dynamic team, and possess a creative and innovative spirit.


You'll have the opportunity to....

  • Develop novel oligonucleotide structures and strategies for use in multiplex biomolecule detection assays
  • Manage oligonucleotide projects, including but not limited to providing key technical knowledge, progress tracking, troubleshooting, and cross-functional team communication
  • Develop advanced knowledge of spatial biology and multispectral imaging of biomolecules
  • Provide significant input to business development vision and strategy in oligonucleotide technology and industry
  • Complete scientific and technical tasks on aggressive timelines, adapt to changing priorities, and manage complex and varied wet lab assignments
  • Follow established standard operating procedures, good laboratory practice, and maintain accurate and complete lab documentation
  • Contribute to strategic projects that support and promote the scientific culture and values of CST
  • Proactively identify, evaluate, and champion new technologies and workflow solutions that will improve quality, efficiency, and/or scalability
  • Engage in personal and professional development activities to ensure currency of own approaches and techniques

Who you are and what you bring to the team....

  • A PhD degree in molecular biophysics, analytical chemistry, biochemistry, organic chemistry, nanotechnology, or materials science 
  • Expertise working in DNA origami nanotechnology
  • Demonstrated success innovating and developing new or emerging chemistries related to nucleic acid synthesis, for example, the design and implementation for synthesis of modified nucleic acids, as evidence by peer-reviewed publications and/or patents
  • Demonstrated knowledge of physical organic chemistry and biophysical chemistry as related to the novel synthesis of biopolymers.
  • Independent investigator with excellent experimental, problem-solving, and analytical skills.
  • Knowledge of tissue immunostaining, fluorescence microscopy, and multiplex immunohistochemistry.
  • Good communication skills for both written and verbal in English.


What we offer....

At Cell Signaling Technology (CST) we recognize that people will always be our most important asset. Providing a safe, inclusive, and stimulating working environment that understands the importance of diversity, human dignity and meaningful work is as important as establishing company policies that incorporate excellent health insurance and pay benefits. We recognize that development of people is the key to their happiness and thus ensure every employee has impactful discussions with their manager and develops actionable performance and professional development plans. Lastly, we are committed to engaging and supporting our employees in committees and philanthropy that benefit their local communities and environment through community investment programs.



  • Medical (BCBS) and Dental (Delta Dental) plans paid at 90%
  • Vision Insurance
  • Life Insurance, Short and Long Term Disability
  • Flexible Spending accounts
  • 401(k) Plan with 6% match
  • Tuition Reimbursement
  • Generous PTO package
  • Pet Insurance
  • Employee Assistance Program
  • Onsite Subsidized Cafeteria
  • Free Parking


Our number one priority is the health and safety of our employees, their families, our communities, partners and customers. In order to promote that safety and well-being, we require that all US-based employees be fully vaccinated against COVID-19 by their start date. Applicants who receive an offer of employment who can provide documentation that the vaccine is medically contraindicated, or who object to vaccination due to a sincerely held religious belief, may make a request for exemption. We will consider requests for reasonable accommodations consistent with our policy, and where we are able to provide such accommodations without undue hardship to the company.


Cell Signaling Technology (CST) is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, status as a veteran or as a member of the military or status in any group protected by applicable federal or state laws.



All resumes submitted by search firms/employment agencies to any employee at Cell Signaling Technology (CST) via email, the internet or in any form and/or method will be deemed the sole property of CST, unless such search firms/employment agencies were engaged by CST for this position and a valid agreement with CST is in place. In the event a candidate who was submitted outside of the CST agency engagement process is hired, no fee or payment of any kind will be paid.


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