Cell Signaling Technology

Scientist - Antibody Engineer

Job Locations US-MA-Beverly
Posted Date 2 months ago(8/24/2020 12:03 PM)
Job ID
Product Development

Company Overview

Cell Signaling Technology, Inc. (CST) is a worldwide leader in the development and commercialization of antibodies, assays and research tools. As a company of scientists for scientists, we have developed PTMScan®, a technology to discover protein post-translational modifications, P hosphoSitePlus®, an online resource for investigation of post-translational modifications, and XMT® technology, a proprietary method to develop exceptional monoclonal antibodies. We are fully committed to developing new research tools to help define the mechanisms underlying cell function and disease, thereby broadly accelerating progress in biomedical research and medicine.

Position Summary

We are seeking a Scientist to join our Antibody Research team which drives development of CST’s antibody technologies of the future. This individual will work in a highly collaborative environment applying antibody and protein engineering, mammalian construct design, and state-of-the-art molecular biology techniques to our extensive catalog of recombinant antibodies. S/he will focus on innovating and developing new engineered antibody product opportunities, as well as enhancing our current products.


  • Design and construct novel antibody variants to be used in a variety of different assay platforms
  • Design and construct antibody-based scaffolds and fusion proteins
  • Express and characterize these molecules in vitro using biochemical and cell-based assays
  • Actively drive exploratory activities from the bench
  • Share and contribute scientific expertise with team members
  • Continuously identify and help to drive technological advancements that lead to more efficient and scalable means of antibody development


  • Ph.D. in biomedical sciences, structural biology, or engineering or related degree plus 2 years postgraduate

Preferred Skills/Experience

  • Experience with molecule design including Fc engineering, multi-specific antibodies, fusion proteins, and optimization of antibody-based scaffolds
  • Expertise in molecular biology tasks such as PCR-based cloning, construct design, site-directed mutagenesis, and vector engineering
  • Experience with protein binding assays (Octet, Biacore, ELISA etc.)
  • Knowledge of antibody optimization techniques such as affinity maturation a plus
  • Experience independently designing, executing, and interpreting scientific experiments
  • Previous work experience in biotechnology and/or pharmaceutical drug development is desirable
  • Passion for science, innovation and creative mind
  • Experience writing, contributing to and publishing scientific papers
  • Proven experience working in a collaborative team environment
  • Demonstrated ability to meet deadlines for multiple projects and priorities simultaneously in a fast-paced environment
  • Self-motivated and comfortable working independently or in cross- functional teams
  • Excellent oral and written communication skills are required

Cell Signaling Technology, Inc. is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, status as a veteran or as a member of the military or status in any group protected by applicable federal or state laws.


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