Cell Signaling Technology

Research Associate – Antigen Design

Job Locations US-MA-Danvers
Posted Date 2 months ago(2/7/2020 1:22 PM)
Job ID
Product Development

Company Overview

Cell Signaling Technology, Inc. (CST) is a worldwide leader in the development and commercialization of antibodies, assays and research tools. As a company of scientists for scientists, we have developed PTMScan®, a technology to discover protein post-translational modifications, P hosphoSitePlus®, an online resource for investigation of post-translational modifications, and XMT® technology, a proprietary method to develop exceptional monoclonal antibodies. We are fully committed to developing new research tools to help define the mechanisms underlying cell function and disease, thereby broadly accelerating progress in biomedical research and medicine.

Position Summary

We are seeking a Research Associate who has a strong background in biochemistry and/or bioinformatics to join the Antigen Design Team. The successful candidate will join a highly collaborative team that provides a centralized resource for the identification of peptide and protein antigens. The antigen design process provides the basis of the successful development of world-class antibodies validated for western analyses and translational applications such as IHC, IF, Flow & ChIP. We analyze each target protein to formulate a comprehensive antigen design and immunization strategy that includes an assessment of antigen type, structural suitability, cross-reactivity risks.


  • Responsible for assessing the target protein biology to develop a comprehensive antigen design strategy
  • Accountable for designing peptide as well as protein antigens for the target proteins with the ultimate goal of developing antibodies
  • Communicate with the Project Scientists to resolve issues
  • Perform data analysis on in-house antigen data and provide insights to improve the antigen design process
  • Responsible for continuously seeking and championing opportunities to improve workflow.


  • BS, BA or MS degree in the field of biological sciences (e.g., biochemistry, biotechnology or bioinformatics)
  • Experience with protein architecture (primary, secondary, tertiary & quaternary)
  • Basic programming/scripting skills (e.g. Python, Perl, Java etc.)


Preferred Skills/Experience

  • Understands basics of molecular interactions involved in protein-protein interactions specifically antigen-antibody interactions
  • Familiarity with DNA/protein analysis software
  • Familiarity with the concepts of statistical analysis and machine learning
  • Strong attention to detail and organizational skills
  • Works successfully in a team environment
  • Strong communication skills (oral and written)
  • Collaborative, team-oriented mindset



Cell Signaling Technology, Inc. is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, status as a veteran or as a member of the military or status in any group protected by applicable federal or state laws.


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