Cell Signaling Technology

  • Senior Research Associate - Proteomics

    Job Locations US-MA-Danvers
    Posted Date 4 months ago(10/24/2019 5:13 PM)
    Job ID
  • Company Overview

    Cell Signaling Technology, Inc. (CST) is a worldwide leader in the development and commercialization of antibodies, assays and research tools. As a company of scientists for scientists, we have developed PTMScan®, a technology to discover protein post-translational modifications, P hosphoSitePlus®, an online resource for investigation of post-translational modifications, and XMT® technology, a proprietary method to develop exceptional monoclonal antibodies. We are fully committed to developing new research tools to help define the mechanisms underlying cell function and disease, thereby broadly accelerating progress in biomedical research and medicine.

    Position Summary

    CST is searching for a Senior Research Associate who will join our Proteomics group and support PTM antibody development projects, collaborate with key labs, and be an important contributor for mass spectrometry-based proteomics method development. The successful candidate will have the opportunity to learn principles and operations of LC-MS/MS as well as proteomics sample preparation.


    • Perform standard biochemical assays such as western blot and ELISA in a timely manner
    • Cell culture and ligand treatment
    • Perform proteomics sample preparation including enzymatic digestion and peptide purification
    • Perform immuno-affinity enrichment and LC-MS/MS analysis of PTM peptides (training provided)
    • Support proteomics antibody development using tools such as PDP, PLM and JIRA
    • Evaluate OEM-in products
    • Prepare samples/antibody reagents for collaborators
    • Effectively summarize and communicate results of testing
    • Write or modify protocols with newly established or improved methods
    • Maintain accurate and complete hard copy and electronic laboratory documentation in appropriate systems (e.g. notebooks, electronic LIMS, JIRA, PDP, PLM, etc.) in accordance with CST quality systems requirements


    • Bachelor’s degree in a biological science (e.g. molecular biology, cell biology, biochemistry or biotechnology)
    • 3+ years' experience in a laboratory environment
    • Previous experience with ELISA, western blotting systems and mammalian cell culture

    Preferred Skills/Experience

    • Familiar with antibody development pipeline
    • Familiar with JIRA, PDP, PLM, LIMS
    • Exposure to LCMS methods and proteomics
    • Experience in immuno-affiity enrichment
    • Strong writing skills
    • Enthusiastic, motivated, with good interpersonal skills
    • Strong organizational skills and record keeping
    • Strong communication skills (written and oral) and the ability to work in a team environment



    Cell Signaling Technology, Inc. is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, status as a veteran or as a member of the military or status in any group protected by applicable federal or state laws.


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