Cell Signaling Technology

  • Computational Biologist

    Job Locations US-MA-Danvers
    Posted Date 4 months ago(9/18/2018 2:39 PM)
    Job ID
  • Company Overview

    Cell Signaling Technology, Inc. (CST) is a worldwide leader in the development and commercialization of antibodies, assays and research tools. As a company of scientists for scientists, we have developed PTMScan®, a technology to discover protein post-translational modifications, P hosphoSitePlus®, an online resource for investigation of post-translational modifications, and XMT® technology, a proprietary method to develop exceptional monoclonal antibodies. We are fully committed to developing new research tools to help define the mechanisms underlying cell function and disease, thereby broadly accelerating progress in biomedical research and medicine.

    Position Summary

    We are seeking a Computational Biologist to join our fast-paced, nimble team and be  responsible for analyzing complex mass spectrometry datasets. As a member of the Bioinformatics group the successful candidate will interpret public and proprietary protein quantification, interaction and posttranslational modification data to drive target selection, antibody development, and downstream biological analysis.


    • Work closely with wet-lab proteomics scientists to collaborate on experimental design and interpretation of mass spectrometry data
    • Identify computational methods, data sources, and external collaborations that will grow capabilities in computational analysis of proteomics data
    • Coordinate with software developers of the Bioinformatics team for the implementation and development of computational and data mining methods
    • Mine public, in-house, and PhosphoSitePlus data for target discovery
    • Develop computational methods for our antibody development pipeline
    • Analyze data for customers of our PTMScan platform
    • Translate data to biological knowledge
    • Communicate complex results to team members, collaborators and customers
    • Publish scientific or methodological results in top journals


    • Masters degree in Bioinformatics or related field
    • Proficiency in writing code in R or Python
    • Proficiency in statistical methods, data mining and machine learning
    • Solid understanding of posttranslational modifications and cell signaling
    • Strong publication record in high impact factor journals

    Preferred Skills/Experience:

    • PhD in Bioinformatics or related field
    • Record of high-throughput analysis of mass spectrometry-based proteomics data
    • Proficiency with C#, PHP, or Java
    • Experience with MySQL, Oracle, graph databases
    • Experience with AWS / Cloud computing
    • Experience with antibody development
    • Minimum 2 years related industry experience or PostDoc

    Cell Signaling Technology, Inc. is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, status as a veteran or as a member of the military or status in any group protected by applicable federal or state laws.


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